Quantified Csf Antibody Reactivity in Multiple Sclerosis: Specificity and Utility in Diagnosis

Xingwen Sun1,2*, Mostafa Bakhti1,2,9, Dirk Fitzner1,2, Mareike Schnaars1,2, Niels Kruse3, Ünal Coskun4,5,6, Christiane Kremser7, Klaus Willecke7, Ludwig Kappos8, Jens Kuhle8 and Mikael Simons1,2 1Max Planck Institute of Experimental Medicine, 37075 Göttingen, Germany 2Department of Neurology, University of Göttingen, 37075 Göttingen, Germany 3Department of Neuropathology, University of Göttingen, 37075 Göttingen, Germany 4Laboratory of Membrane Biochemistry, Paul Langerhans Institute Dresden, Faculty of Medicine Carl Gustav Carus at the TU Dresden, Fetscherstrasse 74, 01307 Dresden, Germany 5German Center for Diabetes Research (DZD), Germany 6Max Planck Institute of Cell Biology and Genetics, 01307 Dresden, Germany 7Molecular Genetics, Life and Medical Sciences Institute, University of Bonn, Carl-Troll-Strasse 31, 53115 Bonn, Germany 8Departments of Neurology and Biomedicine, University Hospital Basel, 4031 Basel, Switzerland 9Institute of Diabetes and Regeneration Research, Helmholtz Zentrum München, Neuherberg, Germany